Base excision repair capacity in informing healthspan
Abstract
Base excision repair (BER) is a frontline defense mechanism for dealing with many common forms of endogenous DNA damage, several of which can drive mutagenic or cell death outcomes. The pathway engages proteins such as glycosylases, abasic endonucleases, polymerases and ligases to remove substrate modifications from DNA and restore the genome back to its original state. Inherited mutations in genes related to BER can give rise to disorders...
Paper Details
Title
Base excision repair capacity in informing healthspan
Published Date
Oct 29, 2014
Journal
Volume
35
Issue
12
Pages
2643 - 2652
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