Original paper
High-Throughput Thermal Scanning for Protein Stability: Making a Good Technique More Robust
Abstract
We present a high-throughput approach to help define experimental formulations that enhance protein stability, which is based on differential scanning fluorimetry (DSF). The method involves defining the thermal stability of a protein against a screen of 13 buffer systems, systematically sampling pH from 5.0 to 9.0 at high and low salt concentrations, using both redundancy and extensive controls to make the method robust. The screen allows rapid...
Paper Details
Title
High-Throughput Thermal Scanning for Protein Stability: Making a Good Technique More Robust
Published Date
Jun 10, 2013
Journal
Volume
15
Issue
8
Pages
387 - 392
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Notes
History