(336) Investigating the neural circuitry supporting clinical pain perception in chronic low back pain – the importance of cardiorespiratory artifact correction with arterial spin labeling fMRI

While brain response to external nociceptive stimuli has been extensively studied, the brain circuitry subserving chronic, clinical pain perception has been more difficult to assess. We implemented a clinical back pain exacerbation procedure using exercises and maneuvers to increase clinical pain severity (Wasan et al., 2011) in 23 patients suffering from nonspecific (non-radicular) chronic Low Back Pain (cLBP). MRI scans were obtained from cLBP...