Discovery of arjunolic acid as a novel non-zinc binding carbonic anhydrase II inhibitor
Abstract
Elevated levels of carbonic anhydrase II (CA II) have been shown to be associated with cardiac hypertrophy and heart failure. Although arjunolic acid (AA) has a diverse range of therapeutic applications including cardio-protection, there have been no reports on the effect of AA on CA II. The present study describes for the first time, the novel zinc independent inhibition of CA II by AA. The molecular docking studies of AA indicated that the...
Paper Details
Title
Discovery of arjunolic acid as a novel non-zinc binding carbonic anhydrase II inhibitor
Published Date
Jun 1, 2016
Journal
Volume
66
Pages
72 - 79
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