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Performance impairment consequent to sleep loss: determinants of resistance and susceptibility.

Published on Nov 1, 2009in Current Opinion in Pulmonary Medicine2.54
· DOI :10.1097/MCP.0b013e3283319aad
Andrew C. King1
Estimated H-index: 1
,
Gregory Belenky41
Estimated H-index: 41
,
Hans P. A. Van Dongen39
Estimated H-index: 39
Cite
Abstract
Purpose of review Five years ago, it was first demonstrated that there are considerable, stable individual differences in performance impairment due to sleep deprivation. The discovery of this new phenotype, which has been labeled ‘trototype’, led to a surge of research activity aiming to identify predictors. Recent findings Genes involved in the adenosinergic and circadian regulation of sleep have been identified as candidate predictors of individuals' resistance or susceptibility to performance impairment resulting from sleep deprivation. Furthermore, brain regions potentially involved in the expression of individual differences in vulnerability to sleep loss have been found. This research has provided new insights into the mechanisms underlying sleep/wake regulation and responses to loss of sleep. To date, however, it remains unknown how much of the phenotypic variability is explained by any of the putative predictors of trototype. Summary The existence of substantial, phenotypic individual differences in performance impairment consequent to sleep loss has important implications for fatigue risk management in operational settings and for the symptomology and treatment of sleep disorders, putting a premium on the discovery of reliable predictors.
  • References (51)
  • Citations (24)
Cite
References51
Newest
William D. S. Killgore43
Estimated H-index: 43
(Harvard University),
Nancy L. Grugle9
Estimated H-index: 9
+ 2 AuthorsThomas J. Balkin41
Estimated H-index: 41
(WRAIR: Walter Reed Army Institute of Research)
Published on Jan 1, 2009in Chronobiology International2.56
Benjamin Edwards12
Estimated H-index: 12
(LJMU: Liverpool John Moores University),
Jim Waterhouse53
Estimated H-index: 53
(LJMU: Liverpool John Moores University)
Sixty subjects were tested five times per waking day on two occasions for accuracy and reliability in throwing 20 darts at a target. Two experimental conditions were investigated: following a normal nocturnal sleep (7–8 h sleep, normal) and after having retired to bed 4 h later than normal the previous night but rising at the normal time (3–4 h sleep, sleep deprivation). Sublingual (core) temperature and subjective estimates of alertness and fatigue were measured in all sessions. Performance at ...
Published on Dec 1, 2008in Journal of Genetics0.82
Malcolm von Schantz27
Estimated H-index: 27
(University of Surrey)
Circadian rhythms and sleep are two separate but intimately related processes. Circadian rhythms are generated through the precisely controlled, cyclic expression of a number of genes designated clock genes. Genetic variability in these genes has been associated with a number of phenotypic differences in circadian as well as sleep parameters, both in mouse models and in humans. Diurnal preferences as determined by the selfreported Horne-Ostberg (HO) questionnaire, has been associated with polymo...
Published on Nov 1, 2008in Current Pharmaceutical Design2.41
Hans-Peter Landolt38
Estimated H-index: 38
To better understand the neurobiology of sleep disorders, detailed understanding of circadian and homeostatic sleep-wake regulation in healthy volunteers is mandatory. Sleep physiology and the repercussions of experimentally- induced sleep deprivation on sleep and waking electroencephalogram (EEG), vigilance and subjective state are highly variable, even in healthy individuals. Accumulating evidence suggests that many aspects of normal sleep-wake regulation are at least in part genetically contr...
Published on Oct 29, 2008in The Journal of Neuroscience6.07
Lisa Y.M. Chuah9
Estimated H-index: 9
,
Mwl Chee36
Estimated H-index: 36
Using 24 h of total sleep deprivation to perturb normal cognitive function, we conducted a double-blind, placebo-controlled crossover study to evaluate the effect of the acetylcholinesterase inhibitor, donepezil, on behavioral performance and task-related brain activation in 28 healthy, young, adult volunteers. The behavioral tasks involved the parametric manipulation of visual short-term memory load and perceptual load in separate experiments indirectly evaluating attention. Sleep deprivation s...
Published on Sep 1, 2008in Journal of Sleep Research3.43
Keith Wong24
Estimated H-index: 24
(National Health and Medical Research Council),
Nathaniel S. Marshall27
Estimated H-index: 27
(National Health and Medical Research Council)
+ 2 AuthorsNaomi L. Rogers25
Estimated H-index: 25
(USYD: University of Sydney)
We hypothesized that individuals with untreated obstructive sleep apnea (OSA) would exhibit greater vulnerability to sleep deprivation than healthy controls, due to the additional neurobiological 'load' of chronic sleep fragmentation. After baseline sleep with 8 h time in bed, participants remained awake for 40 h. Psychomotor Vigilance Task (PVT, mean slowest 10% 1/RT), AusEd Driving Simulator task (steering and speed deviation), and subjective sleepiness (Karolinska Sleepiness Scale, KSS) were ...
Published on Aug 1, 2008in Sleep
John A. Groeger30
Estimated H-index: 30
(University of Surrey),
Antoine Viola18
Estimated H-index: 18
(University of Surrey)
+ 3 AuthorsDerk-Jan Dijk90
Estimated H-index: 90
(University of Surrey)
TASKS DIFFER QUALITATIVELY, IN TERMS OF COGNITIVE PROCESSES REQUIRED FOR THEIR EXECUTION, AND QUANTITATIVELY, IN TERMS OF THE DEMAND imposed on these processes. Some individuals respond to these qualitative and quantitative task demands more successfully than others. Studies have repeatedly shown that cognitive performance deteriorates when people remain continuously awake for long periods of time. Executive functions, which rely on frontal areas of the brain, are thought to be especially compro...
Published on Aug 1, 2008in Current Opinion in Neurology4.65
Mwl Chee36
Estimated H-index: 36
,
Lisa Y.M. Chuah9
Estimated H-index: 9
Purpose of reviewThe review summarizes current knowledge about what fMRI has revealed regarding the neurobehavioral correlates of sleep deprivation and sleep-dependent memory consolidation.Recent findingsFunctional imaging studies of sleep deprivation have characterized its effects on a number of co
Published on Jul 1, 2008in Ergonomics2.18
Robert Schleicher15
Estimated H-index: 15
(Technical University of Berlin),
Niels Galley9
Estimated H-index: 9
(University of Cologne)
+ 1 AuthorsLars Galley2
Estimated H-index: 2
(Daimler AG)
The present study examines changes in a variety of oculomotoric variables as a function of increasing sleepiness in 129 participants, who have been passed through a broad range of subjective alertness. Up to now, spontaneous eye blinks are the most promising biosignal for in-car sleepiness warnings. Reviewing the current literature on eye movements and fatigue, experimental data are provided including additional indicative oculomotoric parameters; inter-individual differences in the experiments ...
Published on Mar 1, 2008in Journal of Sleep Research3.43
Peter L. Franzen18
Estimated H-index: 18
(University of Pittsburgh),
Greg J. Siegle48
Estimated H-index: 48
(University of Pittsburgh),
Daniel J. Buysse79
Estimated H-index: 79
(University of Pittsburgh)
This pilot study examined the relationships between the effects of sleep deprivation on subjective and objective measures of sleepiness and affect, and psychomotor vigilance performance. Following an adaptation night in the laboratory, healthy young adults were randomly assigned to either a night of total sleep deprivation (SD group; n = 15) or to a night of normal sleep (non-SD group; n = 14) under controlled laboratory conditions. The following day, subjective reports of mood and sleepiness, o...
Cited By24
Newest
Published on Nov 1, 2019in NeuroImage5.81
Sahil Bajaj7
Estimated H-index: 7
(UA: University of Arizona),
William D. S. Killgore43
Estimated H-index: 43
(UA: University of Arizona)
Abstract Sleep deprivation (SD) is often associated with significant shifts in mood state relative to baseline functioning. Prior work suggests that there are consistent trait-like differences among individuals in the degree to which their mood and performances are affected by sleep loss. The goal of this study was to determine the extent to which trait-like individual differences in vulnerability/resistance to mood degradation during a night of SD are dependent upon region-specific white and gr...
Published on May 1, 2019in Accident Analysis & Prevention3.06
Amy R. Sparrow2
Estimated H-index: 2
(WSU: Washington State University),
Cynthia M. LaJambe1
Estimated H-index: 1
(PSU: Pennsylvania State University),
Hans P. A. Van Dongen39
Estimated H-index: 39
(WSU: Washington State University)
Abstract Timely detection of drowsiness in Commercial Motor Vehicle (C MV) operations is necessary to reduce drowsiness-related CMV crashes. This is relevant for manual driving and, paradoxically, even more so with increasing levels of driving automation. Measures available for drowsiness detection vary in reliability, validity, usability, and effectiveness. Passively recorded physiologic measures such as electroencephalography (EEG) and a variety of ocular parameters tend to accurately identify...
Published on Jan 1, 2019in International Journal of Psychophysiology2.41
Arcady A. Putilov15
Estimated H-index: 15
(RAS: Russian Academy of Sciences),
Olga G. Donskaya9
Estimated H-index: 9
,
Evgeniy G. Verevkin8
Estimated H-index: 8
Abstract Accurate measurement of objective level of sleepiness can have important implications for experimental and field studies of sleep deprived individuals. We proposed to accurately quantify changes in sleepiness level with single electroencephalographic (EEG) measures obtained from EEG spectra consisting of 16 spectral powers within the frequency interval from 1 to 16 Hz. The EEG signal was recorded every other hour from 19:00 of Friday to 19:00 of Sunday in 48 study participants. The diff...
Published on Mar 16, 2017in Chronobiology International2.56
Arcady A. Putilov15
Estimated H-index: 15
ABSTRACTDifferences between the so-called larks and owls representing the opposite poles of morningness-eveningness dimension are widely known. However, scientific consensus has not yet been reached on the methodology for ranking and typing people along other dimensions of individual variation in their sleep-wake pattern. This review focused on the history and state-of-the-art of the methodology for self-assessment of individual differences in more than one trait or adaptability of the human sle...
Published on Mar 1, 2017in International Journal of Psychophysiology2.41
Arcady A. Putilov15
Estimated H-index: 15
(Academy of Medical Sciences, United Kingdom),
Olga G. Donskaya9
Estimated H-index: 9
(Academy of Medical Sciences, United Kingdom)
Abstract Individual differences in ability to overcome desire to fall asleep cannot be accurately predicted from subjective and objective measurements of sleepiness level. Previously, we showed that an exponential buildup of sleep pressure during prolonged wakefulness can be accurately traced with electroencephalographic (EEG) indexes, such as Spectral Sleep Pressure Component (SSPC) score and score on the 2nd principal component (2PC) of the EEG spectrum. The anterior-posterior gradients in SSP...
Published on Jan 1, 2016
Pia Forsman8
Estimated H-index: 8
,
H.P.A. Van Dongen1
Estimated H-index: 1
Older individuals appear to be relatively resilient to cognitive impairment when sleep deprived. Several explanations have been proposed, including bias towards preserving performance accuracy at the cost of speed, reduced amplitude of circadian rhythm, and slower build-up of sleep pressure during wakefulness. These aging effects are overshadowed by individual differences in performance impairment due to sleep loss that are unrelated to age. Such individual differences are stable and robust, con...
Published on Oct 1, 2015in Frontiers in Neurology2.63
Elise Facer-Childs2
Estimated H-index: 2
(University of Birmingham),
Roland Brandstaetter3
Estimated H-index: 3
(University of Birmingham)
Team performance is a complex phenomenon involving numerous influencing factors including physiology, psychology, and management. Biological rhythms and the impact of circadian phenotype have not been studied for their contribution to this array of factors so far despite our knowledge of the circadian regulation of key physiological processes involved in physical and mental performance. This study involved 216 individuals from 12 different teams who were categorized into circadian phenotypes usi...
Published on Jul 1, 2015in Brain Behavior and Immunity6.17
Brieann C. Satterfield6
Estimated H-index: 6
(WSU: Washington State University),
Jonathan P. Wisor16
Estimated H-index: 16
(Washington State University Spokane)
+ 2 AuthorsHans P. A. Van Dongen39
Estimated H-index: 39
(Washington State University Spokane)
Cytokines such as TNFα play an integral role in sleep/wake regulation and have recently been hypothesized to be involved in cognitive impairment due to sleep deprivation. We examined the effect of a guanine to adenine substitution at position 308 in the TNFα gene (TNFα G308A) on psychomotor vigilance performance impairment during total sleep deprivation. A total of 88 healthy women and men (ages 22-40) participated in one of five laboratory total sleep deprivation experiments. Performance on a p...
Published on May 15, 2015
Serkan Hacar2
Estimated H-index: 2
,
Burcu Türe2
Estimated H-index: 2
Objective: As with other people, sleep quality has an impact on a physician's work safety. Aim of this study is determine the sleep quality among medical specialists whose working night shifts, and detect other independent factors that affect their sleep quality. This is essential for improving the physician health and their daily performance for patient care. Methods: A qualitative study was design with a cross-sectional method. Sampling was con- ducted with stratification among night shift phy...
Published on May 1, 2015in Scientific Reports4.01
Akiko Hida19
Estimated H-index: 19
,
Shingo Kitamura14
Estimated H-index: 14
+ 10 AuthorsYuichi Kamei21
Estimated H-index: 21
A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep–wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness–eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorph...
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