Consider the workhorse: Nonhomologous end-joining in budding yeast
Abstract
DNA double strand breaks (DSBs) are dangerous sources of genome instability and must be repaired by the cell. Nonhomologous end-joining (NHEJ) is an evolutionarily conserved pathway to repair DSBs by direct ligation of the ends, with no requirement for a homologous template. While NHEJ is the primary DSB repair pathway in mammalian cells, conservation of the core NHEJ factors throughout eukaryotes makes the pathway attractive for study in model...
Paper Details
Title
Consider the workhorse: Nonhomologous end-joining in budding yeast
Published Date
Oct 1, 2016
Volume
94
Issue
5
Pages
396 - 406
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