Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.

Volume: 7, Issue: 1, Pages: 11190 - 11190
Published: Apr 6, 2016
Abstract
Senescent cells, formed in response to physiological and oncogenic stresses, facilitate protection from tumourigenesis and aid in tissue repair. However, accumulation of such cells in tissues contributes to age-related pathologies. Resistance of senescent cells to apoptotic stimuli may contribute to their accumulation, yet the molecular mechanisms allowing their prolonged viability are poorly characterized. Here we show that senescent cells...
Paper Details
Title
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL.
Published Date
Apr 6, 2016
Volume
7
Issue
1
Pages
11190 - 11190
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