Long-term Effect of Antihypertensive Therapy with Calcium Antagonist or Angiotensin Converting Enzyme Inhibitor on Serum Nitrite/Nitrate Levels in Human Essential Hypertension

Endothelial function is impaired in hypertension. In the present study the effects of long-term antihypertensive therapy on endothelial production of nitric oxide (NO) were investigated. Fifteen untreated mild to moderate essential hypertensive patients and 13 normotensive subjects were enrolled in this study. Blood pressure, heart rate, lipid profiles, cyclic guanosine 3', 5'-monophosphate (cGMP) and nitrite/nitrate (NOx), which are stable...