F5 The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve HLA Class I Antigen Recognition Groove

Nasopharyngeal carcinoma is a devastating epithelial malignancy facilitated by Epstein Barr Virus infection that claims over 50,000 lives each year, mostly in East Asia. Here we resolve the major genetic influences for NPC incidence using a genome wide association study (GWAS), independent cohort replication, and full molecular HLA Class I gene typing including 4055 study participants from the Guangxi Zhuang Autonomous Region and Guangdong...