Expanding the Ubiquitin Code

The Ubiquitin (Ub) system coordinates vital cellular processes by controlling lifetime, signaling, and binding properties of proteins. Ub serves as a multivalent protein tag that is further diversified by post-translational modifications. Specialized Ub receptors then convert the encoded signals into cellular responses. This SnapShot highlights the importance of the rapidly expanding Ub code in biology as well as novel pharmacological approaches...