Phenotypic characterization of HLA-DQ8-restricted insulin-specific CD4+ T cells in longterm-autoantibody positive children
Abstract
Scientific question: The appearance of multiple islet-autoantibodies in children denotes a point of limited return in the immunepathogenesis of Type 1 Diabetes. However, once islet autoimmunity is established the time frame to overt diabetes is variable ranging from several months to more than two decades. We ask whether such longterm non-progressors will help to identify states of ongoing immune activation vs. regulation when compared to...
Paper Details
Title
Phenotypic characterization of HLA-DQ8-restricted insulin-specific CD4+ T cells in longterm-autoantibody positive children
Published Date
May 6, 2014
Volume
9
Issue
S 01
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