Human Monocytes Engage an Alternative Inflammasome Pathway
Abstract
Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome stimuli. Here, we report that this constituted a species-specific response that is not observed in the murine system. Indeed, in human monocytes, lipopolysaccharide triggered an "alternative inflammasome" that relied on...
Paper Details
Title
Human Monocytes Engage an Alternative Inflammasome Pathway
Published Date
Apr 1, 2016
Journal
Volume
44
Issue
4
Pages
833 - 846
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