Run-to-Run-Based Model Predictive Control of Protein Crystal Shape in Batch Crystallization

In this work, we develop a novel run-to-run-based model predictive controller (R2R-based MPC) for a batch crystallization process with process drift and inherent variation in solubility and crystal growth rates. In order to achieve the production of crystals with desired product qualities, a conventional MPC system with nominal process model parameters is initially applied to a batch protein crystallization process. However, the mismatch between...