Abstract 2906: Curcumin reduces aberrant crypt foci (ACF) number but does not alter prostaglandin E2 (PGE2) or 5-hydroxyeicosanopentaneic acid (5-HETE) concentration in ACF or in normal human colorectal mucosa

Curcumin, a dietary polyphenol derivative of turmeric, has potent cancer preventive activity in in vivo colon carcinogenesis models. To determine whether curcumin has pharmacodynamic effects on the human colon, we administered curcumin at doses of 2 g or 4 g to separate groups of 20 healthy human smokers who had 8 or more aberrant crypt foci on screening colonoscopy. We removed 3 aberrant crypt foci and 4 flat mucosal biopsies under magnifying...