Synthesis, cytotoxicity, and long-term single dose anti-cancer pharmacological evaluation of dimethyltin(IV) complex of N(4)-methylthiosemicarbazone (having ONS donor ligand)

Background and Objective: Toxicity of the chemotherapeutic compounds is widely investigated. An organotin (IV) derivative was designed to modulate the toxicity and long-term anticancer efficacy of the single dose. Materials and Methods: The reaction of dimethyltin(IV) dichloride with N(4)-methylthiosemicarbazone derived by condensation of 4-methylthiosemicarbazone with 5-bromo-2-hydroxybenzaldehyde was prepared in 1:1 M ratio in absolute...