Endothelial nitric oxide synthase tagSNPs influence the effects of enalapril in essential hypertension
Abstract
The antihypertensive effects of angiotensin-converting enzyme inhibitors (ACEi) are associated with up-regulation of endothelial nitric oxide synthase (NOS3) activity. This mechanism may explain how polymorphisms in NOS3 gene affect the antihypertensive responses to ACEi. While clinically relevant NOS3 polymorphisms were previously shown to affect the antihypertensive responses to enalapril, no study has tested the hypothesis that NOS3 tagSNPs...
Paper Details
Title
Endothelial nitric oxide synthase tagSNPs influence the effects of enalapril in essential hypertension
Published Date
May 1, 2016
Journal
Volume
55-56
Pages
62 - 69
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