Infrared spectroscopic serum biomarker profiling of naturally occurring canine knee osteoarthritis

Purpose: The prevalence and consequences of knee OA in domestic dogs parallels those in human patients. The preclinical diagnosis of naturally occurring canine OA, staging, and the monitoring of progression or response to therapy are similarly challenging. Infrared spectroscopy (IR) combined with chemometrics has potential as a clinically relevant and economic biomarker discovery tool, encompassing a range of known and unknown analytes. The...