Transgenerational Effects of Physical Activity Ancestry on Mouse Body Composition, Glucose Metabolism, and Gene Expression

PURPOSE: To examine the influence of a physical activity (PA) ancestry compared to a sedentary (SED) ancestry on body composition, glucose metabolism, and skeletal muscle gene expression in multiple generations of mouse offspring. METHODS: C57/Bl6 mice (F0) were exposed to PA (voluntary wheel running, N=20) or a SED condition (no wheel access, N=20) for 12 weeks prior to breeding. PA males were bred with PA females and SED males were bred with...