Replication protein A: Single‐stranded DNA's first responder
Abstract
Replication protein A (RPA), the major single‐stranded DNA‐binding protein in eukaryotic cells, is required for processing of single‐stranded DNA (ssDNA) intermediates found in replication, repair, and recombination. Recent studies have shown that RPA binding to ssDNA is highly dynamic and that more than high‐affinity binding is needed for function. Analysis of DNA binding mutants identified forms of RPA with reduced affinity for ssDNA that are...
Paper Details
Title
Replication protein A: Single‐stranded DNA's first responder
Published Date
Aug 29, 2014
Journal
Volume
36
Issue
12
Pages
1156 - 1161
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