Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Nature64.80
Volume: 532, Issue: 7598, Pages: 255 - 258
Published: Apr 14, 2016
Abstract
Cells receive growth and survival stimuli through their attachment to an extracellular matrix (ECM). Overcoming the addiction to ECM-induced signals is required for anchorage-independent growth, a property of most malignant cells. Detachment from ECM is associated with enhanced production of reactive oxygen species (ROS) owing to altered glucose metabolism. Here we identify an unconventional pathway that supports redox homeostasis and growth...
Paper Details
Title
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Published Date
Apr 14, 2016
Journal
Volume
532
Issue
7598
Pages
255 - 258
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