Pathological α‐synuclein in gastrointestinal tissues from prodromal Parkinson disease patients

Objective It has been hypothesized that Lewy pathology initiates in the enteric nervous system years prior to debut of clinical motor symptoms in Parkinson disease patients. This study investigates whether Lewy pathology is present in various gastrointestinal tract tissues from Parkinson disease patients in the prodromal phase. Methods We used the Danish National Pathology Registry to identify archived paraffin‐embedded tissue blocks from 57...