Match!

End TB strategy: the need to reduce risk inequalities.

Published on Dec 1, 2016in BMC Infectious Diseases2.565
· DOI :10.1186/s12879-016-1464-8
M. Gabriela M. Gomes21
Estimated H-index: 21
(USP: University of São Paulo),
Mauricio Lima Barreto58
Estimated H-index: 58
(FIOCRUZ: Oswaldo Cruz Foundation)
+ 4 AuthorsS. Bertel Squire25
Estimated H-index: 25
(LSTM: Liverpool School of Tropical Medicine)
Abstract
Background Diseases occur in populations whose individuals differ in essential characteristics, such as exposure to the causative agent, susceptibility given exposure, and infectiousness upon infection in the case of infectious diseases.
  • References (18)
  • Citations (10)
📖 Papers frequently viewed together
720 Citations
4 Citations
2012
3 Authors (Ian Harper, ..., Sally Theobald)
78% of Scinapse members use related papers. After signing in, all features are FREE.
References18
Newest
#1M. Gabriela M. Gomes (USP: University of São Paulo)H-Index: 21
#2Erida Gjini (IGC: Instituto Gulbenkian de Ciência)H-Index: 6
Last. Carlota Rebelo (University of Lisbon)H-Index: 11
view all 5 authors...
Abstract Setting global strategies and targets for disease prevention and control often involves mathematical models. Model structure is typically subject to intense scrutiny, such as confrontation with empirical data and alternative formulations, while a less frequently challenged aspect is the widely adopted reduction of parameters to their average values. Focusing on endemic diseases, we use a general transmission model to explain how mean field approximations decrease the estimated R 0 from ...
5 CitationsSource
#1Tom Wingfield (Imperial College London)H-Index: 12
#2Delia Boccia (Lond: University of London)H-Index: 22
Last. Carlton A. Evans (Imperial College London)H-Index: 34
view all 8 authors...
Background Cash transfers are key interventions in the World Health Organisation’s post-2015 global TB policy. However, evidence guiding TB-specific cash transfer implementation is limited. We designed, implemented and refined a novel TB-specific socioeconomic intervention that included cash transfers, which aimed to support TB prevention and cure in resource-constrained shantytowns in Lima, Peru for: the Community Randomized Evaluation of a Socioeconomic Intervention to Prevent TB (CRESIPT) pro...
19 CitationsSource
PURPOSE OF REVIEW: Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT FINDINGS: There is clear evidence that the timely provision of antiretroviral therapy (ART) reduces mortality in TB/HIV coinfected adults. Despite this, globally in 2013, only aroun...
9 CitationsSource
#1Mukund Uplekar (WHO: World Health Organization)H-Index: 33
#2Diana Weil (WHO: World Health Organization)H-Index: 18
Last. Mario Raviglione (WHO: World Health Organization)H-Index: 87
view all 16 authors...
On May 19, 2014, the 67th World Health Assembly (WHA) adopted WHO’s “Global strategy and targets for tuberculosis prevention, care and control after 2015”. This post-2015 global tuberculosis strategy, labelled the End TB Strategy, was shaped during the past 2 years. A wide range of stakeholders—from ministries of health and national tuberculosis programmes to technical and scientifi c institutions, fi nancial and development partners, civil society and health activists, non-governmental organisa...
281 CitationsSource
#1Jason R. Andrews (Stanford University)H-Index: 34
#2Sanjay Basu (Stanford University)H-Index: 64
Last. Megan Murray (Harvard University)H-Index: 61
view all 4 authors...
Tuberculosis remains disproportionately concentrated among the poor, yet known determinants of tuberculosis reactivation may fail to explain observed disparities in disease rates according to wealth. Reviewing data on tuberculosis disparities in India and the wealth distribution of known tuberculosis risk factors, we describe how social mixing patterns could be contributing to tuberculosis disparities. Wealth-assortative mixing, wherein individuals are more likely to contact others from similar ...
17 CitationsSource
Last. Julio Croda (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 19
view all 16 authors...
Tuberculosis (TB) rates among prisoners are more than 20 times that of the general population in Brazil, yet there are limited data available to facilitate the development of effective interventions in this high-transmission setting. We aimed to assess risk factors for TB infection and evaluate the yield of mass screening for active disease among inmates.
36 CitationsSource
#1Aaron Reeves (University of Oxford)H-Index: 26
#2Sanjay Basu (Stanford University)H-Index: 64
Last. Jan C. Semenza (ECDC: European Centre for Disease Prevention and Control)H-Index: 33
view all 6 authors...
Summary Background WHO stresses the need to act on the social determinants of tuberculosis. We tested whether alternative social protection programmes have affected tuberculosis case notifications, prevalence, and mortality, and case detection and treatment success rates in 21 European countries from 1995 to 2012. Methods We obtained tuberculosis case notification data from the European Centre for Disease Prevention and Control's 2014 European Surveillance System database. We also obtained data ...
27 CitationsSource
To help reach the target of tuberculosis (TB) disease elimination by 2050, vaccine development needs to occur now. We estimated the impact and cost-effectiveness of potential TB vaccines in low- and middle-income countries using an age-structured transmission model. New vaccines were assumed to be available in 2024, to prevent active TB in all individuals, to have a 5-y to lifetime duration of protection, to have 40–80% efficacy, and to be targeted at “infants” or “adolescents/adults.” Vaccine p...
74 CitationsSource
#1Knut Lönnroth (WHO: World Health Organization)H-Index: 47
#2Philippe Glaziou (WHO: World Health Organization)H-Index: 24
Last. Mario Raviglione (WHO: World Health Organization)H-Index: 87
view all 6 authors...
Tuberculosis (TB) remains a major global public health problem. In all societies, the disease affects the poorest individuals the worst. A new post-2015 global TB strategy has been developed by WHO, which explicitly highlights the key role of universal health coverage (UHC) and social protection. One of the proposed targets is that “No TB affected families experience catastrophic costs due to TB.” High direct and indirect costs of care hamper access, increase the risk of poor TB treatment outcom...
50 CitationsSource
#1Tom WingfieldH-Index: 12
#2Delia Boccia (Lond: University of London)H-Index: 22
Last. Carlton A. Evans (Imperial College London)H-Index: 34
view all 8 authors...
Background Even when tuberculosis (TB) treatment is free, hidden costs incurred by patients and their households (TB-affected households) may worsen poverty and health. Extreme TB-associated costs have been termed “catastrophic” but are poorly defined. We studied TB-affected households' hidden costs and their association with adverse TB outcome to create a clinically relevant definition of catastrophic costs. Methods and Findings From 26 October 2002 to 30 November 2009, TB patients (n = 876, 11...
71 CitationsSource
Cited By10
Newest
#1Zhenyu Pan (Xi'an Jiaotong University)H-Index: 4
#2Jun Zhang (Xi'an Jiaotong University)H-Index: 3
Last. Jun Lyu (Xi'an Jiaotong University)H-Index: 4
view all 8 authors...
Objective: The first milestone (in 2020) of the End Tuberculosis (TB) Strategy of the World Health Organization was a 20% reduction in TB incidence rate compared with the 2015 baseline. This study aimed to determine the incidence rate of TB and how it has changed since 2015 at the global, regional, and country levels. Methods: This study used the most recent data from the Global Burden of Disease study in 2017 to extract TB incidence rates at the global, regional, and country levels. The annual ...
Source
#1Maria Rita Bertolozzi (USP: University of São Paulo)H-Index: 14
#2Renata Ferreira Takahashi (USP: University of São Paulo)H-Index: 13
Last. Paula Hino (UNIFESP: Federal University of São Paulo)H-Index: 1
view all 4 authors...
Source
#1James M. Trauer (Monash University)H-Index: 13
#2Peter J. Dodd (University of Sheffield)H-Index: 17
Last. David W. Dowdy (Johns Hopkins University)H-Index: 40
view all 11 authors...
Although less well-recognised than for other infectious diseases, heterogeneity is a defining feature of TB epidemiology. To advance toward TB elimination, this heterogeneity must be better understood and addressed. Drivers of heterogeneity in TB epidemiology act at the level of the infectious host, organism, susceptible host, environment and distal determinants. These effects may be amplified by social mixing patterns, while the variable latent period between infection and disease may mask hete...
4 CitationsSource
#1M. Gabriela M. Gomes (University of Porto)H-Index: 21
#2Juliane F. Oliveira (University of Porto)H-Index: 1
Last. Christian Lienhardt (WHO: World Health Organization)H-Index: 25
view all 10 authors...
Global stakeholders including the World Health Organization rely on predictive models for developing strategies and setting targets for tuberculosis care and control programs. Failure to account for variation in individual risk leads to substantial biases that impair data interpretation and policy decisions. Anticipated impediments to estimating heterogeneity for each parameter are discouraging despite considerable technical progress in recent years. Here we identify acquisition of infection as ...
4 CitationsSource
#1M. Gabriela M. Gomes (University of Porto)H-Index: 21
#1G. Gomes (LSTM: Liverpool School of Tropical Medicine)
Selection acting on unobserved heterogeneity is a fundamental issue in the mathematics of populations. As recognised in disciplines as diverse as demography [11, 23, 24], ecology [10, 9], evolution [21] and epidemiology [1, 4, 5], in any population, individuals differ in many characteristics and it is essential that researchers understand which of these are under selection and how selection processes operate. Here I describe conceptual and methodological developments in demography and ecology, a...
1 CitationsSource
#1Flavio De Maio (UCSC: Catholic University of the Sacred Heart)H-Index: 8
#2Valentina Palmieri (UCSC: Catholic University of the Sacred Heart)H-Index: 18
Last. Massimiliano Papi (UCSC: Catholic University of the Sacred Heart)H-Index: 26
view all 8 authors...
Tuberculosis (TB) remains a global threat and there is an urgent need for improved drugs and treatments, particularly against the drug-resistant strains of Mycobacterium tuberculosis (Mtb). Graphene oxide (GO) is an innovative bi-dimensional nanomaterial that when administered in vivo accumulates in the lungs. Further, GO is readily degraded by peroxidases and has a high drug loading capacity and antibacterial properties. In this study, we first evaluated the GO anti-mycobacterial properties usi...
1 CitationsSource
Last. Jacob CreswellH-Index: 14
view all 9 authors...
Background Tuberculosis (TB) is the deadliest infectious disease globally. Current case finding approaches may miss many people with TB or detect them too late. Data and methods This study was a retrospective, spatial analysis of routine TB surveillance and cadastral data in Go Vap district, Ho Chi Minh City. We geocoded TB notifications from 2011 to 2015 and calculated theoretical yields of simulated door-to-door screening in three concentric catchment areas (50m, 100m, 200m) and three notifica...
Source
#1Aishatu L. Adamu (College of Health Sciences, Bahrain)H-Index: 3
#2Muktar H. Aliyu (Vandy: Vanderbilt University)H-Index: 29
Last. Ibrahim Abubakar (UCL: University College London)H-Index: 57
view all 7 authors...
Successful tuberculosis (TB) treatment is essential to effective TB control. TB-HIV coinfection, social determinants and access to services influenced by rural residence can affect treatment outcome. We examined the separate and joint effects of rural residence and HIV infection on poor treatment outcome among patients enrolled in a large TB treatment centre in Kano, Nigeria. We retrospectively analysed a cohort of patients with TB enrolled in a large urban TB clinic in northern Nigeria, from Ja...
2 CitationsSource
#1M. Gabriela M. Gomes (LSTM: Liverpool School of Tropical Medicine)H-Index: 21
#2Juliane F. Oliveira (University of Porto)H-Index: 1
Last. Christian Lienhardt (WHO: World Health Organization)H-Index: 25
view all 9 authors...
Global stakeholders including the World Health Organization rely on predictive models for developing strategies and setting targets for tuberculosis care and control programs. Failure to account for variation in individual risk leads to substantial biases that impair data interpretation and policy decisions. Anticipated impediments to estimating heterogeneity for each parameter are discouraging despite considerable technical progress in recent years. Here we identify acquisition of infection as ...
1 CitationsSource
#1Jon Zelner (UM: University of Michigan)H-Index: 5
#2Megan Murray (Harvard University)H-Index: 61
Last. Ted Cohen (Yale University)H-Index: 39
view all 9 authors...
Background: Untargeted active screening and treatment programmes for tuberculosis (TB) have not been shown to be more effective than passive screening and isoniazid preventive therapy (IPT) for reducing TB incidence. In this manuscript, we compare the efficacy of targeting screening and IPT on high-risk household contacts of diagnosed TB cases, with less-targeted active screening approaches in Lima, Peru. Methods: We conducted a population-based prospective cohort study within households of TB c...
5 CitationsSource