Inhibition of ATP-sensitive potassium channels attenuates propofol-induced vasorelaxation

Infusion of propofol often causes significant vasodilation, which is followed by a profound drop in blood pressure. However, the exact underlying molecular mechanisms of this clinically important phenomenon remain unclear.To determine the biological role of endothelium in propofol-induced vasorelaxation and the underlying molecular mechanisms of this response in the rat aorta.Ex vivo assessment of vasomotor function in rat aortic rings, with or...