MTH1 Substrate Recognition—An Example of Specific Promiscuity
Abstract
MTH1 (NUDT1) is an oncologic target involved in the prevention of DNA damage. We investigate the way MTH1 recognises its substrates and present substrate-bound structures of MTH1 for 8-oxo-dGTP and 8-oxo-rATP as examples of novel strong and weak binding substrate motifs. Investigation of a small set of purine-like fragments using 2D NMR resulted in identification of a fragment with weak potency. The protein-ligand X-Ray structure of this...
Paper Details
Title
MTH1 Substrate Recognition—An Example of Specific Promiscuity
Published Date
Mar 21, 2016
Journal
Volume
11
Issue
3
Pages
e0151154 - e0151154
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