HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
Abstract
Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor B cells. Critical unmet challenges are to determine whether bnAb precursor naïve B cells bind germline-targeting immunogens and occur at sufficient frequency in humans for reliable vaccine responses. Using deep mutational scanning and multitarget optimization, we...
Paper Details
Title
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
Published Date
Mar 25, 2016
Journal
Volume
351
Issue
6280
Pages
1458 - 1463
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