SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
Abstract
SIRT6 belongs to the mammalian homologs of Sir2 histone NAD(+)-dependent deacylase family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal tissues. It remains unknown whether human SIRT6 has a direct role in maintaining the homeostasis of mesodermal tissues. To this end, we generated SIRT6 knockout human mesenchymal stem cells (hMSCs) by targeted gene editing. SIRT6-deficient hMSCs exhibited accelerated...
Paper Details
Title
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
Published Date
Jan 15, 2016
Journal
Volume
26
Issue
2
Pages
190 - 205
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