From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases

Chronic venous disease ( CVD ) and its most frightening complication, chronic venous ulceration ( CVU ), represent an important socioeconomic burden in the western world. Metalloproteinases have been identified in the pathogenesis of several vascular diseases such as venous problems. The aim of this study was to evaluate a broad range of metalloproteinases, such as matrix metalloproteinases ( MMPs ), ADAMs (a disintegrin and metalloproteinases)...