Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o

Volume: 473, Issue: 10, Pages: 1379 - 1390
Published: May 11, 2016
Abstract
Transient receptor potential canonical 4 (TRPC4) forms non-selective cation channels implicated in the regulation of diverse physiological functions. Previously, TRPC4 was shown to be activated by the Gi/o subgroup of heterotrimeric G-proteins involving Gαi/o, rather than Gβγ, subunits. Because the lifetime and availability of Gα-GTP are regulated by regulators of G-protein signalling (RGS) and Gαi/o-Loco (GoLoco) domain-containing proteins via...
Paper Details
Title
Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o
Published Date
May 11, 2016
Volume
473
Issue
10
Pages
1379 - 1390
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