Extramedullary Myeloid Sarcoma With Eosinophilia and FIP1L1-Pdgfra Rearrangement: Complete Cytogenetic Response To Imatinib Therapy

Background Myeloid sarcomas are rare extramedullary manifestations of acute myeloid leukemia (AML) representing less then 1% of all cases. Since they invariably progress into systemic disease, early AML-like chemotherapy is mandated. Myeloproliferations with eosinophilia and involvement of the PDGFRA, PDGFRB or FGFR1 genes are distinct entities in the 2008 WHO classification with peculiar sensitivity to tyrosine kinase inhibitors. Extramedullary...