New insights into the endophenotypic status of cognition in bipolar disorder: Genetic modelling study of twins and siblings

Twin studies have lacked statistical power to apply advanced genetic modelling techniques to the search for cognitive endophenotypes for bipolar disorder.To quantify the shared genetic variability between bipolar disorder and cognitive measures.Structural equation modelling was performed on cognitive data collected from 331 twins/siblings of varying genetic relatedness, disease status and concordance for bipolar disorder.Using a parsimonious AE...