One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli
Abstract
Poly(lactate-co-glycolate) (PLGA) is a widely used biodegradable and biocompatible synthetic polymer. Here we report one-step fermentative production of PLGA in engineered Escherichia coli harboring an evolved polyhydroxyalkanoate (PHA) synthase that polymerizes D-lactyl-CoA and glycolyl-CoA into PLGA. Introduction of the Dahms pathway enables production of glycolate from xylose. Deletion of ptsG enables simultaneous utilization of glucose and...
Paper Details
Title
One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli
Published Date
Mar 7, 2016
Journal
Volume
34
Issue
4
Pages
435 - 440
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