Mycobacterial escape from macrophage phagosomes to the cytoplasm represents an alternate adaptation mechanism
Abstract
Survival of Mycobacterium tuberculosis (Mtb) within the host macrophage is mediated through pathogen-dependent inhibition of phagosome-lysosome fusion, which enables bacteria to persist within the immature phagosomal compartment. By employing ultrastructural examination of different field isolates supported by biochemical analysis, we found that some of the Mtb strains were in fact poorly adapted for subsistence within endocytic vesicles of...
Paper Details
Title
Mycobacterial escape from macrophage phagosomes to the cytoplasm represents an alternate adaptation mechanism
Published Date
Mar 16, 2016
Journal
Volume
6
Issue
1
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