PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast
Abstract
The structure of a C11 peptidase PmC11 from the gut bacterium, Parabacteroides merdae, has recently been determined, enabling the identification and characterization of a C11 orthologue, PNT1, in the parasitic protozoon Trypanosoma brucei. A phylogenetic analysis identified PmC11 orthologues in bacteria, archaea, Chromerids, Coccidia, and Kinetoplastida, the latter being the most divergent. A primary sequence alignment of PNT1 with clostripain...
Paper Details
Title
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast
Published Date
Apr 1, 2016
Volume
291
Issue
18
Pages
9492 - 9500
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