Conformational dynamics of a membrane protein chaperone enables spatially regulated substrate capture and release

Significance Molecular chaperones play key roles in maintaining protein homeostasis within cells. Membrane protein chaperones face particular challenges, as they not only protect highly aggregation-prone membrane protein substrates, but also need to achieve tight spatiotemporal coordination of their chaperone cycle. In this work, biochemical and NMR analyses address these questions and for the first time, to our knowledge, define the complete...