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Autoantibody Production in Cancer - The Humoral Immune Response toward Autologous Antigens in Cancer Patients

Published on May 1, 2016in Autoimmunity Reviews7.72
· DOI :10.1016/j.autrev.2016.01.017
Pauline Zaenker2
Estimated H-index: 2
(ECU: Edith Cowan University),
Elin S. Gray29
Estimated H-index: 29
(ECU: Edith Cowan University),
Melanie Ziman24
Estimated H-index: 24
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Abstract
A link between autoimmune responses and cancer via autoantibodies was first described in the 1950s. Since, autoantibodies have been studied for their potential use as cancer biomarkers, however the exact causes of their production remain to be elucidated. This review summarizes current theories of the causes of autoantibody production in cancer, namely: 1) defects in tolerance and inflammation, 2) changes in protein expression levels, 3) altered protein structure, and 4) cellular death mechanisms. We also highlight the need for further research into this field to improve our understanding of autoantibodies as biomarkers for cancer development and progression.
  • References (78)
  • Citations (31)
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References78
Newest
#1Christine G. Joseph (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Erika Darrah (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 13
Last.Isaac Kinde (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
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#1Ludmil B. Alexandrov (Wellcome Trust Sanger Institute)H-Index: 42
#2Serena Nik-Zainal (University of Cambridge)H-Index: 37
Last.Anne Lise Børresen-DaleH-Index: 39
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#1Brian Burford ('KCL': King's College London)H-Index: 6
#2A Gentry-Maharaj (UCL: University College London)H-Index: 12
Last.Anne Dawnay (UCL: University College London)H-Index: 29
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#1Emily Stamell Ruiz (Albert Einstein College of Medicine)H-Index: 5
#2Jedd D. WolchokH-Index: 100
Last.Isaac Brownell (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 12
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#1Pawel Zayakin (Latvian Biomedical Research and Study centre)H-Index: 5
#2Guntis Ancāns (LU: University of Latvia)H-Index: 1
Last.Agnese Ruskule (LU: University of Latvia)H-Index: 1
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#1Milena Music (U of T: University of Toronto)
#2Antoninus Soosaipillai (MSH: Mount Sinai Hospital, Toronto)H-Index: 35
Last.Eleftherios P. DiamandisH-Index: 97
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#1Chang-Kyu Heo (Korea Research Institute of Bioscience and Biotechnology)
#2Hai-min Hwang (Korea Research Institute of Bioscience and Biotechnology)H-Index: 1
Last.Eun-Wie Cho (Korea Research Institute of Bioscience and Biotechnology)H-Index: 10
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#1Fatemeh Kiaee (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 5
#2Gholamreza AziziH-Index: 16
Last.Laleh Sharifi (Tehran University of Medical Sciences)H-Index: 5
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#1Yabin Zhou (USTB: University of Science and Technology Beijing)
#2Jiawen Cui (USTB: University of Science and Technology Beijing)
Last.Hongwu Du (USTB: University of Science and Technology Beijing)H-Index: 16
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#1Mario MantoH-Index: 30
#2Hiroshi Mitoma (TMU: Tokyo Medical University)H-Index: 11
Last.Christiane S. Hampe (UW: University of Washington)H-Index: 26
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