Strategies to Determine Off-Target Effects of Engineered Nucleases
Abstract
Genome editing is greatly facilitated by using engineered nucleases to specifically cleave a pre-selected DNA sequence. Cellular repair of the nuclease-induced DNA breaks by either non-homologous end joining (NHEJ) or homology-directed repair (HDR) allows genome editing in a wide range of organisms and cell lines. However, if a nuclease cleaves at genomic locations other than the intended target, known as “off-target sites”, it can lead to...
Paper Details
Title
Strategies to Determine Off-Target Effects of Engineered Nucleases
Published Date
Jan 1, 2016
Pages
187 - 222
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