An Investigation of the Atomic Structure of Cataract-Forming Mutant Gamma-D-Crystallin Aggregates Formed under Distinct Environmental Conditions
Abstract
Human gamma-D-crystallin (HGD) is an extremely soluble (>400mg/mL in vivo) and stable protein that under certain conditions succumbs to protein aggregation, which is associated with cataract formation. Cataracts are the leading cause of blindness globally. Both environmental and genetic factors enable cataract formation by disrupting the solubility of HGD. Several chemical modifications are thought to be linked to loss of solubility and...
Paper Details
Title
An Investigation of the Atomic Structure of Cataract-Forming Mutant Gamma-D-Crystallin Aggregates Formed under Distinct Environmental Conditions
Published Date
Feb 1, 2016
Journal
Volume
110
Issue
3
Pages
27a - 27a
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