Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors
Abstract
Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains limited. Here, we identify a functionally distinct subset of BP3−PDPN+PDGFRβ+/α+CD34+ stromal adventitial cells in both lymph nodes (LNs) and thymus that is located within the vascular niche surrounding PDPN−PDGFRβ+/α−Esam-1+ITGA7+ pericytes. CD34+ adventitial cells developed in late...
Paper Details
Title
Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors
Published Date
Mar 1, 2016
Journal
Volume
14
Issue
10
Pages
2375 - 2388
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