Calcium Channel Blockade and Peroxisome Proliferator Activated Receptor ? Agonism Diminish Cognitive Loss and Preserve Endothelial Function During Diabetes Mellitus

Diabetes mellitus is considered as a main risk factor for vascular dementia. In the past, we have reported the induction of vascular dementia (VaD) by experimental diabetes. This study investigates the efficacy of a nifedipine, a calcium channel blocker and pioglitazone in the pharmacological interdiction of pancreatectomy diabetes (PaD) induced vascular endothelial dysfunction and subsequent VaD in rats. Attentional set shifting (ASST) and...