A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2
Abstract
The generation of induced pluripotent stem cells (iPSCs) from differentiated cells following forced expression of OCT4, KLF4, SOX2, and C-MYC (OKSM) is slow and inefficient, suggesting that transcription factors have to overcome somatic barriers that resist cell fate change. Here, we performed an unbiased serial shRNA enrichment screen to identify potent repressors of somatic cell reprogramming into iPSCs. This effort uncovered the protein...
Paper Details
Title
A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2
Published Date
May 1, 2016
Journal
Volume
6
Issue
5
Pages
704 - 716
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