Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
Abstract
Antibodies with ontogenies from VH1-2 or VH1-46-germline genes dominate the broadly neutralizing response against the CD4-binding site (CD4bs) on HIV-1. Here, we define with longitudinal sampling from time-of-infection the development of a VH1-46-derived antibody lineage that matured to neutralize 90% of HIV-1 isolates. Structures of lineage antibodies CH235 (week 41 from time-of-infection, 18% breadth), CH235.9 (week 152, 77%), and CH235.12...
Paper Details
Title
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
Published Date
Apr 1, 2016
Journal
Volume
165
Issue
2
Pages
449 - 463
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