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Insulin sensitivity and glucose effectiveness: minimal model analysis of regular and insulin-modified FSIGT

Published on Apr 1, 1998in American Journal of Physiology-endocrinology and Metabolism4.13
· DOI :10.1152/ajpendo.1998.274.4.E592
Giovanni Pacini52
Estimated H-index: 52
(National Research Council),
Giancarlo Tonolo31
Estimated H-index: 31
(University of Sassari)
+ 5 AuthorsR. Nosadini17
Estimated H-index: 17
(University of Sassari)
Cite
Abstract
The minimal model is widely used to evaluate insulin action on glucose disappearance from frequently sampled intravenous glucose tolerance tests (FSIGT). The common protocols are a regular (rFSIGT, single injection of 0.3 g/kg of glucose) and an insulin-modified test (mFSIGT, with an additional insulin administration at 20 min). This study compared the insulin sensitivity index (SI) and glucose effectiveness (SG) obtained in the same individual (16 normal subjects) with the two tests. SI was 7.11 ± 0.80 10−4 ⋅ min−1 ⋅ μU−1 ⋅ ml in rFSIGT and 6.96 ± 0.83 in mFSIGT ( P = 0.656), regression r = 0.92, P < 0.0001; SG was 0.0260 ± 0.0028 min−1 and 0.0357 ± 0.0052, respectively, statistically different ( P = 0.013) but still with a good regression ( r = 0.66, P = 0.0051). SG and insulin amount during the early period correlated ( r = 0.6, P = 0.015 in rFSIGT and r = 0.76, P = 0.0006 in mFSIGT). In summary, both FSIGTs with minimal model analysis provide the same SI, which is a very robust index. SG was different by 28% due probably to the relationship between SG and the amount of circulating insulin. In studies comparing groups, the simpler rFSIGT can still be used with the advantage of accounting for endogenous insulin, thus offering the possibility of direct inferences on the β-cell activity.
  • References (33)
  • Citations (89)
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References33
Newest
Published on Nov 1, 1997in Diabetes7.20
Ta-Chen Ni2
Estimated H-index: 2
,
Marilyn Ader28
Estimated H-index: 28
,
Richard N. Bergman103
Estimated H-index: 103
Minimal model analysis with the frequently sampled intravenous glucose tolerance test provides an effective way to measure two important metabolic parameters in vivo under non-steady-state conditions: glucose effectiveness ( S G ) and insulin sensitivity ( S I ). Two questions regarding the validity of S G and S I have recently emerged. First, S G from the minimal model is suspected to be overestimated. Second, the occurrence of S I values indistinguishable from zero (“zero- S I ”) is not neglig...
Bo Ahrén87
Estimated H-index: 87
(Lund University),
Giovanni Pacini52
Estimated H-index: 52
This study examined whether insulin secretion, insulin sensitivity, glucose effectiveness, and hepatic extraction of insulin are altered in subjects with impaired glucose tolerance (IGT). The frequently sampled intravenous glucose tolerance test was performed in postmenopausal women (age 63 yr, body mass index range 21.6–28.9 kg/m2) with IGT (n = 10) or normal glucose tolerance (NGT; n = 10). Insulin sensitivity (SI) was significantly lower in IGT than in NGT (P = 0.030). In contrast, insulin se...
Published on Jul 1, 1997in Diabetes7.20
Mohammed F. Saad73
Estimated H-index: 73
,
Garry M. Steil40
Estimated H-index: 40
+ 5 AuthorsRichard N. Bergman103
Estimated H-index: 103
The insulin-modified frequently sampled Intravenous glucose tolerance test (FSIGTT) with minimal model analysis (MINMOD) was compared with the tolbutamide protocol and the glucose clamp in 35 nondiabetic subjects (age 38 ± 2 years [mean ± SE], BMI 27.2 ± 0.9 kg/m 2 ). Each subject underwent two FSIGTTs, one with tolbutamide (300 mg) and the other with insulin (0.03 U/kg) and a euglycemic hyperinsulinemic clamp (40 mU · m −2 · min −1 ). Insulin sensitivity was determined from each FSIGTT with MIN...
A. Mari1
Estimated H-index: 1
Insulin sensitivity is frequently assessed with the minimal model (MM) and the insulin-modified intravenous glucose tolerance test (MIVGTT). To ascertain the validity of this approach, the mechanisms by which the MM estimates glucose effectiveness and insulin sensitivity (SG and SI, respectively) from the data are analyzed theoretically. Published data and new labeled MIVGTTs in normal and non-insulin-dependent diabetic (NIDDM) subjects are used as reference data. One reason for the reported dif...
Published on Mar 15, 1997in Journal of Clinical Investigation12.28
Marilyn Ader28
Estimated H-index: 28
,
Ta-Chen Ni2
Estimated H-index: 2
,
Richard N. Bergman103
Estimated H-index: 103
Glucose tolerance is determined by both insulin action and insulin-independent effects, or “glucose effectiveness,” which includes glucose-mediated stimulation of glucose uptake (R d ) and suppression of hepatic glucose output (HGO). Despite its importance to tolerance, controversy surrounds accurate assessment of glucose effectiveness. Furthermore, the relative contributions of glucose’s actions on R d and HGO under steady state and dynamic conditions are unclear. We performed hyperglycemic cla...
Published on Mar 1, 1997in Diabetes7.20
Ananda Basu41
Estimated H-index: 41
,
Andrea Caumo31
Estimated H-index: 31
(UniSR: Vita-Salute San Raffaele University)
+ 4 AuthorsRobert A. Rizza81
Estimated H-index: 81
People with NIDDM are resistant to insulin. The present studies sought to determine whether the ability of glucose to regulate its own metabolism in the presence of basal insulin concentrations is impaired. To address this question, basal insulin concentrations were maintained constant with an exogenous insulin infusion, while endogenous hormone secretion was inhibited by somatostatin. The integrated glycemic response above baseline during identical prandial glucose infusions was greater (1,411 ...
Published on Mar 1, 1997in IFAC Proceedings Volumes
Karl Thomaseth25
Estimated H-index: 25
,
Claudio Cobelli83
Estimated H-index: 83
(UNIPD: University of Padua)
Abstract In the identification of physiological systems it is often of practical interest knowing which time intervals during experiments provide most information on specific estimated model parameters. A common approach is based on visual inspection of the time courses of model output sensitivities determined for each parameter separately. This kind of analysis is however limited if strong correlation between parameter estimates is present. For this purpose, three approaches, based on different...
D. T. Finegood1
Estimated H-index: 1
(U of A: University of Alberta),
D. Tzur1
Estimated H-index: 1
(U of A: University of Alberta)
We previously demonstrated that minimal model-derived estimates of glucose effectiveness (SG), based on the frequently sampled intravenous glucose tolerance test (SGFSIGT), were reduced in islet-tr...
Published on Sep 1, 1996in Diabetes Care15.27
James D. Best47
Estimated H-index: 47
,
Steven E. Kahn91
Estimated H-index: 91
+ 3 AuthorsRichard N. Bergman103
Estimated H-index: 103
Published on Jan 15, 1996in Journal of Clinical Investigation12.28
Ronald L. Prigeon30
Estimated H-index: 30
,
Michael E. Røder3
Estimated H-index: 3
+ 1 AuthorsSteven E. Kahn91
Estimated H-index: 91
Administration of exogenous insulin during an intravenous glucose tolerance test allows the use of the minimal model technique to determine the insulin sensitivity index in subjects with reduced endogenous insulin responses. To study the effect of different insulin administration protocols, we performed three intravenous glucose tolerance tests in each of seven obese subjects (age, 20-41 yr; body mass index, 30-43 kg/m2). Three different insulin administration protocols were used: a low-dose (0....
Cited By89
Newest
Published on Mar 9, 2019in Journal of Endocrinological Investigation
Jing Zhang4
Estimated H-index: 4
(SJTU: Shanghai Jiao Tong University),
Huating Li17
Estimated H-index: 17
(SJTU: Shanghai Jiao Tong University)
+ 11 AuthorsChen Wang12
Estimated H-index: 12
(SJTU: Shanghai Jiao Tong University)
Purpose The ileum-derived fibroblast growth factor 19 (FGF19) plays key roles in hepatic glucose homeostasis in animals in an insulin-independent manner. Here, we analyzed the association of FGF19 with glucose effectiveness (GE, the insulin-independent glucose regulation), as well as hepatic glucose production (HGP) in Chinese subjects.
Published on Jan 1, 2019in Diabetes & Metabolism Journal
Veronica Falcone2
Estimated H-index: 2
(Medical University of Vienna),
Grammata Kotzaeridi (Medical University of Vienna)+ 8 AuthorsP. Husslein (Medical University of Vienna)
Published on Oct 1, 2018in Acta Diabetologica3.00
Micaela Morettini6
Estimated H-index: 6
(Marche Polytechnic University),
Francesco Di Nardo12
Estimated H-index: 12
(Marche Polytechnic University)
+ 5 AuthorsAndrea Tura31
Estimated H-index: 31
Aims Minimal model analysis of intravenous glucose tolerance test (IVGTT) data represents the reference method to assess insulin sensitivity (SI) and glucose effectiveness (SG) that quantify the insulin-dependent and insulin-independent processes of glucose disappearance, respectively. However, test duration (3 h) and need for modeling expertise limit the applicability of this method. Aim of this study was providing a simple predictor of SG applicable to short test (1 h), as previously done with...
Published on Jun 11, 2017
Micaela Morettini6
Estimated H-index: 6
(Marche Polytechnic University),
Francesco Di Nardo12
Estimated H-index: 12
(Marche Polytechnic University)
+ 3 AuthorsLaura Burattini14
Estimated H-index: 14
(Marche Polytechnic University)
Glucose effectiveness (SG) represents the ability of glucose per se, under basal insulin concentrations, to stimulate its own uptake and to suppress its own production. SG and its two components BIE (Basal Insulin Effect) and GEZI (Glucose Effectiveness at Zero Insulin) are known to decline in subjects whose glycemic status worsens, but no study aimed to analyze whether changes may occur even before, when a normal glucose tolerance status is still preserved but insulin resistance has already ari...
Published on Jun 1, 2017in Physiological Reports
Giovanni Pacini52
Estimated H-index: 52
,
Bo Ahrén87
Estimated H-index: 87
(Lund University)
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) stimulate insulin secretion. They are both released after meal ingestion, and therefore they might cooperate in their actions. However, whether there is a cooperative action of the two incretins is not known. This study therefore investigated the effects on insulin secretion and glucose disappearance of GLP-1 and GIP when given together with intravenous glucose both alone and in combination in mice. Four different...
Published on Apr 1, 2017in Fertility and Sterility5.41
Peiwen Liang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University),
Liuqing Xi2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
+ 11 AuthorsLihui Yuan1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University)
Objective To compare the prevalence of polycystic ovary syndrome (PCOS) and related clinical characteristics between metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) women of reproductive age. Design Cross-sectional clinical study. Setting Tertiary hospital. Patient(s) We studied 299 MUO and 122 MHO Chinese women matched on body mass index. Metabolically healthy obese was defined as obesity with no more than one metabolic abnormality. Diagnosis of PCOS was based on the r...
Published on Mar 1, 2017in BMJ open diabetes research & care
Toh Peng Yeow3
Estimated H-index: 3
(Penang Medical College),
Giovanni Pacini52
Estimated H-index: 52
(National Research Council)
+ 8 AuthorsJens J. Holst148
Estimated H-index: 148
(UCPH: University of Copenhagen)
Objective Youth onset type 2 diabetes mellitus (YT2DM) is a globally rising phenomenon with substantial Asians representation. The understanding of its pathophysiology is derived largely from studies in the obese African-American and Caucasian populations, while studies on incretin effect are scarce. We examined the insulin resistance, β-cell function (BC), glucagon-like peptide (GLP)-1 hormone and incretin effect in Asian YT2DM. Research design and methods This case–control study recruited 25 A...
Saloni Rathee1
Estimated H-index: 1
(DCE: Delhi Technological University),
Nilam2
Estimated H-index: 2
(DCE: Delhi Technological University)
Diabetes also known as diabetes mellitus is a chronic and complex metabolic disease due to the persistent raised blood glucose concentration for long duration. The mechanism behind the disturbed glucose-insulin dynamics is still not fully understood. The mathematical models which describe the glucose homeostasis, different aspects of diabetes and its consequences are growing rapidly, provide new insights into the biological mechanism involved and help in the management of diabetes. Here, contrib...
Published on Dec 1, 2016in Cardiovascular Diabetology5.95
Julia Szendroedi27
Estimated H-index: 27
(HHU: University of Düsseldorf),
Aaruni Saxena4
Estimated H-index: 4
(HHU: University of Düsseldorf)
+ 10 AuthorsDan Ziegler49
Estimated H-index: 49
(HHU: University of Düsseldorf)
Background The German Diabetes Study (GDS) is a prospective longitudinal cohort study describing the impact of subphenotypes on the course of the disease. GDS aims at identifying prognostic factors and mechanisms underlying the development of related comorbidities.
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