Histones as mediators of host defense, inflammation and thrombosis
Abstract
Histones are known for their ability to bind to and regulate expression of DNA. However, histones are also present in cytoplasm and extracellular fluids where they serve host defense functions and promote inflammatory responses. Histones are a major component of neutrophil extracellular traps that contribute to bacterial killing but also to inflammatory injury. Histones can act as antimicrobial peptides and directly kill bacteria, fungi,...
Paper Details
Title
Histones as mediators of host defense, inflammation and thrombosis
Published Date
Mar 1, 2016
Journal
Volume
11
Issue
3
Pages
441 - 453
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Notes
History