Prevalence of Malignancies in Patients With Primary Aldosteronism

Primary aldosteronism (PA) is the most common cause of secondary hypertension. Aldosterone excess can cause DNA damage in vitro and in vivo. Single case reports have indicated a coincidence of PA with renal cell carcinoma and other tumors. However, the prevalence of benign and malignant neoplasms in patients with PA has not yet been studied.In the multicenter MEPHISTO study, the prevalence of benign and malignant tumors was investigated in 335...