An ankylosing spondylitis-associated genetic variant in theIL23R-IL12RB2intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation

Objectives

To explore the functional basis for the association between ankylosing spondylitis (AS) and single-nucleotide polymorphisms (SNPs) in the IL23R-IL12RB2 intergenic region.

Methods

We performed conditional analysis on genetic association data and used epigenetic data on chromatin remodelling and transcription factor (TF) binding to identify the primary AS-associated IL23R-IL12RB2 intergenic SNP....