Toward the Definition of a Bipolar Prodrome: Dimensional Predictors of Bipolar Spectrum Disorders in At-Risk Youths.

Published on Jul 1, 2016in American Journal of Psychiatry13.655
· DOI :10.1176/appi.ajp.2015.15040414
Danella Hafeman16
Estimated H-index: 16
John Merranko7
Estimated H-index: 7
+ 10 AuthorsBoris Birmaher7
Estimated H-index: 7
Objective:The authors sought to assess dimensional symptomatic predictors of new-onset bipolar spectrum disorders in youths at familial risk of bipolar disorder (“at-risk” youths).Method:Offspring 6–18 years old of parents with bipolar I or II disorder (N=359) and community comparison offspring (N=220) were recruited. At baseline, 8.4% of the offspring of bipolar parents had a bipolar spectrum disorder. Over 8 years, 14.7% of offspring for whom follow-up data were available (44/299) developed a new-onset bipolar spectrum disorder (15 with bipolar I or II disorder). Measures collected at baseline and follow-up were reduced using factor analyses, and factors (both at baseline and at the visit prior to conversion or last contact) were assessed as predictors of new-onset bipolar spectrum disorders.Results:Relative to comparison offspring, at-risk and bipolar offspring had higher baseline levels of anxiety/depression, inattention/disinhibition, externalizing, subsyndromal manic, and affective lability symptoms...
Figures & Tables
  • References (0)
  • Citations (71)
📖 Papers frequently viewed together
94 Citations
6,158 Citations
232 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
Cited By71
#1Tae Young Lee (PNU: Pusan National University)
#1Taeyoung LeeH-Index: 28
Last. Sungwon RohH-Index: 12
view all 17 authors...
Background: The Seoul Pluripotent Risk for Mental Illness (SPRIM) study was designed to identify predictors leading to mental illness in help-seeking individuals by securing sufficient statistical power through transdiagnostic approaches. The SPRIM study aims to examine the clinical characteristics of high-risk individuals for mental illness and to identify proteomic biomarkers that can predict the onset of mental illness. Methods: This paper describes the study protocol of the SPRIM study. We a...
#1Anne Duffy (Queen's University)H-Index: 31
#2Gabrielle A. Carlson (SBU: Stony Brook University)H-Index: 60
Last. M H J Hillegers (EUR: Erasmus University Rotterdam)H-Index: 1
view all 4 authors...
BACKGROUND: Evidence from epidemiological, clinical and high-risk studies has established that the peak period of risk for onset of bipolar disorder spans late adolescence and early adulthood. However, the proposal of the existence of a pre-pubertal form of bipolar disorder manifesting in early childhood created substantial debate. In this narrative review, the literature and contributing factors pertaining to the controversy surrounding the proposed pre-pubertal bipolar disorder subtype are dis...
2 CitationsSource
#2Naomi A. FinebergH-Index: 44
Last. Filippo DragoH-Index: 47
view all 15 authors...
Abstract Objectives To investigate whether mood instability (MI) qualify as a trait marker for bipolar disorder (BD) we investigated: 1) differences in smartphone-based self-reported MI between three groups: patients with newly diagnosed BD, unaffected first-degree relatives (UR), and healthy control individuals (HC); 2) the correlation between MI and functioning, stress, and duration of illness, respectively; and 3) the validity of smartphone-based self-evaluated mood ratings as compared to obs...
#1E. De la SernaH-Index: 5
#2Daniel IlzarbeH-Index: 1
Last. V. Sanchez-Gistau (Institut Pere Mata)H-Index: 6
view all 11 authors...
Having one parent diagnosed with a severe mental disorder is considered one of the main risk factors for developing that disorder in adulthood, and it also increases the risk of a wide range of mental disorders in the offspring. The aim of this study is to compare the prevalence of several psychopathological diagnoses, the presence of prodromal symptoms, and global functioning in offspring of parents with schizophrenia or bipolar disorder and in offspring of controls at baseline and 2-year follo...
#1Robert M. PostH-Index: 117
#2Benjamin I. Goldstein (Sunnybrook Health Sciences Centre)H-Index: 41
Last. David J. Miklowitz (UCLA: University of California, Los Angeles)H-Index: 63
view all 7 authors...
Abstract Background : Approaches to early intervention and prevention of childhood onset bipolar and related disorders are not well delineated despite the need and the negative impact of untreated illness. Methods : We reviewed the meager literature that does exist, and attempt to characterize how preliminary are the data supporting each of the possible suggestions. However, given the ability to characterize children at high risk based on family history, childhood adversity, and prodromal sympto...
#1Karolina Leopold (TUD: Dresden University of Technology)H-Index: 13
#2Michael Bauer (TUD: Dresden University of Technology)H-Index: 71
Last. Sarah Kittel-SchneiderH-Index: 21
view all 22 authors...
OBJECTIVE: Most patients with bipolar disorders (BD) exhibit prodromal symptoms before a first (hypo)manic episode. Patients with clinically significant symptoms fulfilling at-risk criteria for serious mental illness (SMI) require effective and safe treatment. Cognitive-behavioral psychotherapy (CBT) has shown promising results in early stages of BD and in patients at high risk for psychosis. We aimed to investigate whether group CBT can improve symptoms and functional deficits in young patients...
#1Stefan Kloiber (U of T: University of Toronto)H-Index: 28
#2Joshua D. Rosenblat (CAMH: Centre for Addiction and Mental Health)H-Index: 17
Last. Jair C. Soares (University of Texas Health Science Center at Houston)H-Index: 67
view all 11 authors...
Abstract Aberrations in neurodevelopmental trajectories have been implicated in the neurobiology of several mental disorders and evidence indicates a pathophysiological and genetic overlap of schizophrenia and bipolar disorder (BD). In this narrative review, we summarize findings related to developmental and perinatal factors as well as epidemiological, clinical, neuropsychological, brain imaging, postmortem brain and genomic studies that provide evidence for a putative neurodevelopmental pathog...
#1Siann Bowman (La Trobe University)H-Index: 4
#2Carol McKinstry (La Trobe University)H-Index: 10
Last. Patrick D. McGorry (University of Melbourne)H-Index: 109
view all 4 authors...
AIM: Young people experiencing mental ill health are more likely than their healthy aged peers to drop out of high school. This can result in social exclusion and vocational derailment. Identifying young people at risk and taking action before an illness is established or school dropout occurs is an important goal. This study aimed to examine evidence for the risk markers and at risk mental states of the clinical staging model (stage 0-1b) and whether these risk states and early symptoms impact ...