Control of Foxp3 stability through modulation of TET activity
Abstract
Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine and other oxidized methylcytosines, intermediates in DNA demethylation. In this study, we examine the role of TET proteins in regulating Foxp3, a transcription factor essential for the development and function of regulatory T cells (T reg cells), a distinct lineage of CD4+ T cells that prevent autoimmunity and maintain immune homeostasis. We show...
Paper Details
Title
Control of Foxp3 stability through modulation of TET activity
Published Date
Feb 22, 2016
Volume
213
Issue
3
Pages
377 - 397
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