Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia

Blood20.30
Volume: 126, Issue: 23, Pages: 674 - 674
Published: Dec 3, 2015
Abstract
null null Background: There remains a critical requirement for novel therapies for Acute Myeloid Leukemia (AML). Bromodomain and extra-terminal domain (BET) inhibitors are emerging as exciting therapeutic agents for hematopoietic malignancies. Pharmacological inhibition of BET bromodomains targets malignant cells by preventing reading of acetylated lysine residues, thus disrupting chromatin-mediated signal transduction, which reduces...
Paper Details
Title
Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia
Published Date
Dec 3, 2015
Journal
Volume
126
Issue
23
Pages
674 - 674
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