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Prediction and validation of total and regional skeletal muscle volume using B-mode ultrasonography in Japanese prepubertal children

Published on Oct 1, 2015in British Journal of Nutrition3.319
· DOI :10.1017/S0007114515002585
Taishi Midorikawa12
Estimated H-index: 12
(J. F. Oberlin University),
Megumi Ohta7
Estimated H-index: 7
(Chukyo University)
+ 2 AuthorsShizuo Sakamoto12
Estimated H-index: 12
(Waseda University)
Abstract
Very few effective field methods are available for accurate, non-invasive estimation of skeletal muscle volume (SMV) and mass in children. We aimed to develop regression-based prediction equations for SMV, using ultrasonography, in Japanese prepubertal children, and to assess the validity of these equations. In total, 145 healthy Japanese prepubertal children aged 6-12 years were randomly divided into two groups: the model development group (sixty boys, thirty-seven girls) and the validation group (twenty-nine boys, nineteen girls). Reference data in the form of contiguous MRI with 1-cm slice thickness were obtained from the first cervical vertebra to the ankle joints. The SMV was calculated by the summation of digitised cross-sectional areas. Muscle thickness was measured using B-mode ultrasonography at nine sites in different regions. In the model development group, strong, statistically significant correlations were observed between the site-matched SMV (total, arms, trunk, thigh and lower legs) measured by MRI and the muscle thickness×height measures obtained by ultrasonography, for both boys and girls. When these SMV prediction equations were applied to the validation groups, the measured total and regional SMV were also very similar to the values predicted for boys and girls, respectively. With the exception of the trunk region in girls, the Bland-Altman analysis for the validation group did not indicate any bias for either boys or girls. These results suggest that ultrasonography-derived prediction equations for boys and girls are useful for the estimation of total and regional SMV.
  • References (13)
  • Citations (5)
References13
Newest
3 CitationsSource
#1Taishi MidorikawaH-Index: 12
#2Megumi Ohta (Waseda University)H-Index: 7
Last. Shizuo Sakamoto (Waseda University)H-Index: 12
view all 6 authors...
The present study was performed to develop regression-based prediction equations for fat mass by ultrasound in Japanese children and to investigate the validity of these equations. A total of 127 healthy Japanese pre-pubertal children aged 6–12 years were randomly separated into two groups: the model development group (fifty-four boys and forty-four girls) and the validation group (eighteen boys and eleven girls). Total body, trunk, arm and leg fat masses were initially determined by dual-energy...
6 CitationsSource
#1Taishi Midorikawa (Waseda University)H-Index: 12
#2Kiyoshi Sanada (Waseda University)H-Index: 20
Last. Takashi Abe (Tokyo Metropolitan University)H-Index: 48
view all 4 authors...
The purpose of the present study was to investigate whether ultrasound-derived prediction equations for estimating total and regional skeletal muscle (SM) mass in adults are applicable for prepubertal children and adolescents. Ten Japanese prepubertal children and twenty-one adolescents volunteered for the study. Contiguous MRI images with a 1 cm slice thickness were obtained from the first cervical vertebra to the ankle joints as reference data. The SM volume was calculated from the summation o...
13 CitationsSource
#1Jaehee Kim (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 10
#2Wei Shen (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 33
Last. Steven B. Heymsfield (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 123
view all 8 authors...
Background: Skeletal muscle (SM) is an important compartment but is difficult to quantify in children and adolescents. Objective: We investigated the potential of dual-energy X-ray absorptiometry (DXA) for measuring total-body SM in pediatric subjects. Design: A previously published adult DXA SM prediction formula was evaluated in children and adolescents aged 5-17 y (n = 99) who varied in pubertal maturation stage. SM estimated by whole-body magnetic resonance imaging (MRI) was used as the refe...
83 CitationsSource
#1Kiyoshi Sanada (Tokyo Metropolitan University)H-Index: 20
#2Charles F. Kearns (Tokyo Metropolitan University)H-Index: 10
Last. Takashi Abe (Tokyo Metropolitan University)H-Index: 48
view all 4 authors...
The present study was performed to develop regression-based prediction equations for skeletal muscle (SM) mass by ultrasound and to investigate the validity of these equations in Japanese adults. Seventy-two Japanese men (n=38) and women (n=34) aged 18–61 years participated in this study and were randomly separated into two groups: the model development group (n=48) and the validation group (n=24). The total and regional SM mass were measured using magnetic resonance imaging (MRI) 1.5 T-scanners...
119 CitationsSource
POORTMANS, J. R., N. BOISSEAU, J.-J. MORAINE, R. MORENO-REYES, and S. GOLDMAN. Estimation of Total-Body Skeletal Muscle Mass in Children and Adolescents. Med. Sci. Sports Exerc., Vol. 37, No. 2, pp. 316–322, 2005. Purpose: The estimation of total-body skeletal muscle mass (SMM) has been predicted in healthy adults using anthropometric measurements and urine creatinine excretion. SMM measurement is compulsory to evaluate exercise performance and the influence of physical training on muscle mass. ...
75 CitationsSource
#1Takashi AbeH-Index: 48
#2Charles F. KearnsH-Index: 10
Last. T. FukunagaH-Index: 58
view all 3 authors...
Objectives: To determine sex differences in the distribution of regional and total skeletal muscle (SM) using contiguous whole body magnetic resonance imaging (MRI) data, and to examine the relations between fat free mass (FFM) and total and regional SM masses. Methods: A total of 20 Japanese college students (10 women and 10 men) volunteered for the study. FFM was measured by two compartment densitometry. Whole body MRI images were prepared using a 1.5 T scanner. Contiguous transverse images wi...
128 CitationsSource
#1Amy Hsu (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 1
#2Stanley Heshka (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 26
Last. Dympna Gallagher (Mount Sinai St. Luke's and Mount Sinai Roosevelt)H-Index: 66
view all 7 authors...
Background: Children have a high resting energy expenditure (REE) relative to their body weight. The decline in REE during growth may be due to changes in body composition or to changes in the metabolic rate of individual organs and tissues. Objectives: The goals were to quantify body-composition components in children at the organ-tissue level in vivo and to determine whether the observed masses 1) account for the elevated REE in children and 2) account, when combined with specific organ-tissue...
51 CitationsSource
#1Tim J. ColeH-Index: 122
#2Mary C BellizziH-Index: 3
Last. William H. DietzH-Index: 99
view all 4 authors...
Objective To develop an internationally acceptable definition of child overweight and obesity, specifying the measurement, the reference population, and the age and sex specific cut off points. Design International survey of six large nationally representative cross sectional growth studies. Setting Brazil, Great Britain, Hong Kong, the Netherlands, Singapore, and the United States. Subjects 97 876 males and 94 851 females from birth to 25 years of age. Main outcome measure Body mass index (weig...
12k CitationsSource
#1Takashi Abe (Tokyo Metropolitan University)H-Index: 48
#2Masakatsu KondoH-Index: 7
Last. T. Fukunaga (UTokyo: University of Tokyo)H-Index: 58
view all 4 authors...
A total of 117 Japanese subjects (62 men and 55 women) volunteered for the study. Subcutaneous adipose tissue (AT) and muscle thicknesses were measured by B-mode ultrasonography at nine sites of the body. Body density (BD) was determined the hydrodensitometry. Reproducibility of thickness measurements by ultrasonography was high (r = 0.96–0.99). Correlations between AT thickness and BD ranged from −0.46 (gastrocnemius) to −0.87 (abdomen) for males and −0.46 (gastrocnemius) to −0.84 (abdomen) for...
172 CitationsSource
Cited By5
Newest
#1Taishi Midorikawa (J. F. Oberlin University)H-Index: 12
#2Yuki Hikihara (Chiba Institute of Technology)H-Index: 10
Last. Shigeho TanakaH-Index: 21
view all 7 authors...
In this study, we ascertained the relationship between resting energy expenditure (REE) obtained using two procedures: indirect calorimetry and from organ-tissue mass, calculated employing magnetic resonance imaging (MRI), and adult metabolic rate constants, in prepubertal children. Differences between the measured and the calculated REEs were assessed according to age at puberty approaching stage. We recruited 6–12 years old 110 healthy Japanese prepubertal children (40 girls and 70 boys). Orga...
Source
#1Chengsi Ong (NUS: National University of Singapore)H-Index: 4
#2Jan Hau Lee (NUS: National University of Singapore)H-Index: 15
Last. Zudin Puthucheary (UCL: University College London)H-Index: 21
view all 4 authors...
Evidence suggests that critically ill children develop muscle wasting, which could affect outcomes. Muscle ultrasound has been used to track muscle wasting and association with outcomes in critically ill adults but not children. This review aims to summarize methodological considerations of muscle ultrasound, structural findings, and possibilities for its application in the assessment of nutrition and functional outcomes in critically ill children. Medline, Embase, and CINAHL databases were sear...
3 CitationsSource
#1Megumi Ohta (Chukyo University)H-Index: 7
#2Taishi MidorikawaH-Index: 12
Last. Hiroaki Kanehisa (National Institute of Fitness and Sports in Kanoya)H-Index: 56
view all 7 authors...
Purpose We hypothesized that body mass-to-waist ratio is strongly associated with the total-body skeletal muscle volume (SMV) in children. The purpose of the present study was to examine this hypothesis. Methods By using magnetic resonance imaging, total-body SMV (SMVMRI) was determined in 70 boys and 53 girls aged 6 to 12 years. Waist was measured at each of the level of umbilicus (Wumb) and the minimum circumference (Wmin), and the ratio of body mass to each of the two measured values was calc...
2 CitationsSource
#1Matt S. Stock (UCF: University of Central Florida)H-Index: 5
#2Jacob A. Mota (TTU: Texas Tech University)H-Index: 6
Last. Brennan J. Thompson (USU: Utah State University)H-Index: 17
view all 4 authors...
INTRODUCTION: We examined correlations among echo intensity and muscle thickness versus measures of athleticism and isometric strength in healthy children. METHODS: B-mode ultrasonography was used to examine the vastus lateralis (VL) and rectus femoris (RF) in 28 boys (mean age = 12 years). Tests of athleticism included jump height and peak velocity, sprint speed, and agility. Peak torque and the rate of torque development (RTD) at 100 and 200 ms from torque onset were assessed. RESULTS: Several...
5 CitationsSource
#1Taishi Midorikawa (J. F. Oberlin University)H-Index: 12
#2Megumi Ohta (Chukyo University)H-Index: 7
Last. Shizuo Sakamoto (Waseda University)H-Index: 12
view all 5 authors...
We aimed to develop regression-based prediction equations for estimating total and regional skeletal muscle mass (SMM) from measurements of lean soft tissue mass (LSTM) using dual-energy X-ray absorptiometry (DXA) and investigate the validity of these equations. In total, 144 healthy Japanese prepubertal children aged 6–12 years were divided into 2 groups: the model development group (62 boys and 38 girls) and the validation group (26 boys and 18 girls). Contiguous MRI images with a 1-cm slice t...
4 CitationsSource