Stimulation with bone morphogenetic protein-2 (BMP-2) enhances bone–tendon integrationin vitro

Preclinical studies have reported that bone morphogenetic protein (BMP)-2 promotes bone-tendon healing following anterior cruciate ligament reconstruction. We examined the region-specific effects of BMP-2 on osteoblast and fibroblast differentiation in a highly standardized murine in vitro co-culture model of bone-tendon integration.We used quantitative PCR to measure the dose- and time-dependent influence of BMP-2 on the expression of alkaline...